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Levitra (Vardenafil HCl) is used for treating erectile dysfunction. Erectile dysfunction or erectile impotency means the penis is unable to perform at its maximum level to fulfill its role during sexual intercourse. Levitra is an orange colored, round, film coated tablets which usually is taken 20-30 minutes before having sex. Each tablet contains microcrystalline cellulose, crospovidone, colloidal silicon dioxide, magnesium stearate, hypromellose, polyethylene glycol, titanium dioxide, yellow ferric oxide, and red ferric oxide. Erection happens when the smooth muscles in the corpus cavernosum and its accompanying arterioles begins to relax. During sexual spur, the nerve ends of the corpus cavernosum releases nitric oxde, which in turn stimulates the enzyme guanylate cyclase resulting to and inscresed level of cyclic guanosine monophosphate which leads to the vasodilation of the corpus cavernosum. This will increase the blood flow in the penis.
Augmenting the action of the enzyme PDE5, responsible for the biotransformation of cGMP in the corpus cavernosum, the drug optimizes the effect of the endogenous nitric oxide, which is locally released in the corpus cavernosum during sexual spur. Levitra enhances the usual reaction to sexual spur.
For most patients, the recommended starting dose of LEVITRA is 10 mg, taken orally approximately 1 hour prior sexual intercourse. Dosage may be intesified to a maximum recommended dose of 20 mg. The dosage may also be reduced to 5 mg. This will vary according to how the patient reacts to the drug.
Patients who are 65 yrs old are given 5 mg as the starting dose. The dosage of LEVITRA may require adjustment in patients receiving potent CYP3A4 inhibitors such as ketoconazole, itraconazole, ritonavir, indinavir, saquinavir, atazanavir, and clarithromycin as well as in other patients receiving moderate CYP3A4 inhibitors such as erythromycin. There is always a need to be cautios every time you take synthetic medicines. Be sure to consult your doctors first.